Microsoft Defender multi Tenant managment

I work for an MSP that is going to switch out our current our current Antivirus Platform (Carbon Black) for another product.

We are thinking about using MS defender as a reseller...either as an independent product or also going full O365 and migrating our clients from on Premise Exchange to 365 Exchange.

However, I can't find anyone who manages MS defender (or Exchange for that matter) as a multi-tenant client.    Each of our customers I understand would have their own instance and tenant ID, but I don't see any MSP managing these clients through a single interface.

I have heard of Lighthouse and read about the API integration for MS defender, but I have yet to come across any companies using it in this fashion.   

Has anyone heard of managing a large client base for MS defender (or any MS cloud product) through successfully through Lighthouse or any other means?